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S-Adenosyl Methionine


SAMe is a combination of the amino acid methionine and a methyl group. From a chemistry standpoint, SAMe has the ability to accelerate and maintain various metabolic reactions throughout the body. 

 Depression and osteoarthritis are the two most extensively studied disorders where an associated deficiency in SAMe has been established. After 1-2 months of the compound building up in your body, SAMe has been shown to be as effective as prescription antidepressants in some individuals. However, symptom improvement has been reported occurring within as little as 2-3 days.

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It's For?

  • Depression (↓↓)

  • Osteoarthritis symptoms (↓↓)


To Take?

  • Recommended dose: 200-1,200mg per day, divided into two or three doses.


To Know?

  • Some reported adverse effects include increased gas, upset stomach, diarrhea, constipation, dry mouth, headache, dizziness, anxiety, and skin rashes

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Links to Some Recommended Products

  • Pros: Amazon's product of choice.

  • Pros: Most reviewed SAMe product. 

  • Cons: Slightly more expensive and lower rating than "Nature's Trove" brand. 

  • Pros: Slightly more affordable than other options.

  • Cons: Less reviews. 

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